Epilepsy is a clinically and etiologically heterogeneous brain disorder that remains difficult to treat in one third of patients. Our team aims to identify novel genes and genetic mechanisms implicated in epilepsy, as well as genetic modifiers influencing disease outcome and expression, using advanced multi-omics strategies. To translate our genetic work into biological insights, we use iPSC derived neuronal cultures and brain organoids, enabling us to model disease-relevant mechanisms and to identify and validate novel therapeutic targets. 

In parallel, we conduct clinical research to define genotype–phenotype correlations, uncover clinical predictors of disease severity, and support clinical trial readiness for rare epilepsies and neurodevelopmental disorders. By integrating deep clinical phenotyping with cutting-edge functional genomics, our work bridges the gap between bench and bedside to advance precision medicine for individuals with epilepsy.